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    1. Cell Biology
    2. Computational and Systems Biology

    A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

    Renat N Khaliullin, Rebecca A Green ... Karen Oegema
    Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan, Max Collard ... Kira E Poskanzer
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
    1. Neuroscience

    Resolving multisensory and attentional influences across cortical depth in sensory cortices

    Remi Gau, Pierre-Louis Bazin ... Uta Noppeney
    The different laminar profiles observed across the cortical depth for multisensory and attentional influences indicate partly distinct neural circuitries of information-flow control.
    1. Cell Biology

    Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

    Kerstin Klinkert, Nicolas Levernier ... Pierre Gönczy
    Experiments reveal mechanisms through which Caenorhabditis elegans zygotes depleted of Aurora A or lacking centrosomes spontaneously establish two posterior PAR-2 domains, one at each pole, in a curvature-dependent manner.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis, Jakob Voigts ... Emery N Brown
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Neuroscience

    Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness

    Oluwaseun Akeju, Marco L Loggia ... Patrick L Purdon
    Patterns of communication between the thalamus and the cortex are correlated with anesthesia-induced loss of consciousness and recovery.
    1. Neuroscience

    Frequency-specific neural signatures of perceptual content and perceptual stability

    Richard Hardstone, Matthew W Flounders ... Biyu J He
    While perceptual content is encoded in non-oscillatory activity in the slow cortical potential (<5 Hz) range, perceptual stability is predominantly influenced by the amplitude fluctuations of alpha (~10 Hz) and beta (~20 Hz) brain oscillations.
    1. Neuroscience

    UP-DOWN cortical dynamics reflect state transitions in a bistable network

    Daniel Jercog, Alex Roxin ... Jaime de la Rocha
    Population cortical recordings and computational network modeling support a novel mechanism underlying spontaneous UP-DOWN dynamics consisting on non-rhythmic transitions between a silent attractor and a low-rate inhibition-stabilized attractor.
    1. Cell Biology

    Cortical regulation of cell size by a sizer cdr2p

    Kally Z Pan, Timothy E Saunders ... Fred Chang
    It is shown that fission yeast cells sense their size by measuring their surface area through a membrane-associated sizer protein cdr2p.