RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.
ATAC-seq, transcriptomics, and transcription factor motif searches collaborate to build a network that regulates gene expression in different cortical layers.
The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
Cortical oscillations in human MEG are lamina-specific, with low-frequency activity predominating in deep, and high-frequency activity in more superficial layers of sensory and motor cortices.
Subtypes of dendrite-targeting somatostatin cells segregate into separate networks by specifically connecting with neurons in different layers, forming circuits that could independently control different input pathways to the neocortex.
Longitudinal imaging of synapses in the brain shows that sensory deprivation differentially modifies specific synapses within individual neurons across distinct layers of the sensory cortex.
Novel evidence for a role of feedback in the perception of uniform surfaces in the human brain suggests that feedback already re-enters at an early visual processing stage.