By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
A set of genes that are turned on only within time-limited windows—including genes encoding RNA binding molecules, let-7 microRNAs and IMP1—control developmental switches in stem cell properties between fetal development and adulthood.
PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
A number of genes associated with the development of brain tumors are epigenetically repressed in specialized astrocytes to enable the production of neurons in the postnatal brain.
Male and female mice respond differently to the same pheromone signals, and the representation of these sensory stimuli by neurons in the medial amygdala correlates precisely with the differences in behavior.
Flow cytometric isolation and fate mapping shows that neurosphere-initiating cells are highly mitotically active and persist only transiently in vivo, and are distinct from quiescent, long-lived neural stem cells.