305 results found
    1. Neuroscience

    Neuroscience: What's new is older

    Lara M Rangel, Howard Eichenbaum
    Version of Record
    Insight
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng, Mark Mayford, Fred H Gage
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun, Zhiqiang Dong ... Su Guo
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Stem Cells and Regenerative Medicine

    A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

    Jinsuke Nishino, Sunjung Kim ... Sean J Morrison
    A set of genes that are turned on only within time-limited windows—including genes encoding RNA binding molecules, let-7 microRNAs and IMP1—control developmental switches in stem cell properties between fetal development and adulthood.
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu, Jessica M Appler ... Lisa V Goodrich
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple knockout mouse models reveal lincRNAs are required for life and brain development

    Martin Sauvageau, Loyal A Goff ... John L Rinn
    Long intergenic noncoding RNA molecules (lincRNAs) are shown to have critical roles in mammalian development and physiology in vivo.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Distinct and separable roles for EZH2 in neurogenic astroglia

    William W Hwang, Ryan D Salinas ... Daniel A Lim
    A number of genes associated with the development of brain tumors are epigenetically repressed in specialized astrocytes to enable the production of neurons in the postnatal brain.
    1. Neuroscience

    Sex-specific processing of social cues in the medial amygdala

    Joseph F Bergan, Yoram Ben-Shaul, Catherine Dulac
    Male and female mice respond differently to the same pheromone signals, and the representation of these sensory stimuli by neurons in the medial amygdala correlates precisely with the differences in behavior.
    1. Stem Cells and Regenerative Medicine

    Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

    John K Mich, Robert AJ Signer ... Sean J Morrison
    Flow cytometric isolation and fate mapping shows that neurosphere-initiating cells are highly mitotically active and persist only transiently in vivo, and are distinct from quiescent, long-lived neural stem cells.

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