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    1. Cell Biology
    2. Developmental Biology

    Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division

    Felipe Mora-Bermúdez, Fumio Matsuzaki, Wieland B Huttner
    Mammalian neural stem cells specifically regulate a subset of astral microtubules to govern the subtle changes in spindle orientation that underlie symmetric vs asymmetric cell division during embryonic cortical neurogenesis.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa, Pamela Bielli ... Claudio Sette
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Genetics and Genomics
    2. Neuroscience

    MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

    Michael J Lafferty, Nil Aygün ... Jason L Stein
    Inter-individual differences in miRNA expression during fetal cortical development informs genetic mechanisms for complex brain phenotypes.
    1. Cell Biology
    2. Developmental Biology

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell, Helen Chen ... Christopher A Maxwell
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Developmental Biology
    2. Neuroscience

    Adult-born neurons modify excitatory synaptic transmission to existing neurons

    Elena W Adlaf, Ryan J Vaden ... Linda Overstreet-Wadiche
    The formation of new neurons in the adult dentate gyrus causes a proportion of cortical neurons to transfer their existing connections to the newborn cells.
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello, Christophe Galichet ... Robin Lovell-Badge
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.
    1. Developmental Biology

    E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

    Gwenvael Le Dréau, René Escalona ... Elisa Marti
    Rather than acting as passive and neutral co-factors for proneural proteins, E proteins play an active role in modulating the way the distinct proneural proteins instruct neurogenesis.
    1. Cell Biology
    2. Developmental Biology

    miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

    Eleonora Franzoni, Sam A Booker ... F Gregory Wulczyn
    The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Neuroscience

    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

    Jormay Lim, Hsiao-Hsin Tai ... Jaw-Lin Wang
    Mouse brain neurons response to transcranial ultrasound at the energy level of 5 mW/cm2 and repeated stimulations lead to neurogenesis while ASIC1a is required both in vitro and in vivo as one of the mechanoreceptors.