402 results found
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom, Chaolin Zhang ... Robert B Darnell
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Stem Cells and Regenerative Medicine

    A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

    Jinsuke Nishino, Sunjung Kim ... Sean J Morrison
    A set of genes that are turned on only within time-limited windows—including genes encoding RNA binding molecules, let-7 microRNAs and IMP1—control developmental switches in stem cell properties between fetal development and adulthood.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua, Philip M Smallwood, Jeremy Nathans
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Distinct and separable roles for EZH2 in neurogenic astroglia

    William W Hwang, Ryan D Salinas ... Daniel A Lim
    A number of genes associated with the development of brain tumors are epigenetically repressed in specialized astrocytes to enable the production of neurons in the postnatal brain.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Re-examining how complexin inhibits neurotransmitter release

    Thorsten Trimbuch, Junjie Xu ... Christian Rosenmund
    Challenging a widespread model, biophysical and electrophysiological experiments suggest a new mechanism whereby complexins inhibit neurotransmitter release through electrostatic repulsion between their accessory helix and the membranes.
    1. Cell Biology
    2. Neuroscience

    Complete morphologies of basal forebrain cholinergic neurons in the mouse

    Hao Wu, John Williams, Jeremy Nathans
    The first complete 3D structures of mouse cholinergic neurons reveal the length and complexity of their axons, while calculations suggest that equivalent axons in the human brain are approximately than 100 meters long.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith, Yaohong Wu ... William D Snider
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.
    1. Neuroscience

    Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

    Il Hwan Kim, Hong Wang ... Ryohei Yasuda
    Conditional knockout of the small GTPase Cdc42 in excitatory neurons of the mouse forebrain leads to impaired long-term synaptic plasticity and impaired retrieval of remote memory.
    1. Neuroscience

    Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

    Liora Garion, Uri Dubin ... Jackie Schiller
    Neurons within rat somatosensory cortex are selective to texture and are spatially organized according to their texture preference.

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