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    1. Developmental Biology
    2. Neuroscience

    Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF

    Haruka Sato, Jun Hatakeyama ... Kenji Shimamura
    VGF was identified as a factor secreted from thalamocortical axons essential for the cytoarchitectonic features of neocortical layer 4 in the sensory areas in mice.
    1. Neuroscience

    FMRP regulates postnatal neuronal migration via MAP1B

    Salima Messaoudi, Ada Allam ... Isabelle Caille
    A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
    1. Cell Biology

    The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons

    Yi-Ju Chen, Shun-Cheng Tseng ... Eric Hwang
    The protein hyaluronan-mediated motility receptor interacts with microtubules to enhance their stability and recruits TPX2 to promote microtubule emanation in neurons.
    1. Developmental Biology
    2. Neuroscience

    Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

    Ayse Güven, Nereo Kalebic ... Wieland B Huttner
    Transcription factor Sox9 has an important role in neocortex expansion, where its expression in basal progenitors increases proliferation, induces premature gliogenesis and promotes the expression of extracellular matrix components.
    1. Developmental Biology

    Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

    Rana Amini, Archit Bhatnagar ... Caren Norden
    Horizontal cell undergoes amoeboid-like migration in the developing vertebrate retina, a not previously reported migration mode in the central nervous system, that allows them to move within a densely packed tissue without predetermined paths.
    1. Developmental Biology

    MicroRNA-934 is a novel primate-specific small non-coding RNA with neurogenic function during early development

    Kanella Prodromidou, Ioannis S Vlachos ... Rebecca Matsas
    Primate-specific miR-934 mediates neurogenesis and downstream neuronal differentiation processes, modulating the expression of genes associated with the subplate, a region most prominent in primates, emerging during early cortical development.
    1. Neuroscience

    Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth

    Samora Okujeni, Ulrich Egert
    Activity-dependent neurite outgrowth and neuronal migration interact to shape modular mesoscale network architecture by homeostatic self-organization.
    1. Neuroscience
    2. Physics of Living Systems

    Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome

    Murat Yildirim, Chloe Delepine ... Mriganka Sur
    Label-free three-photon imaging of whole, uncleared intact organoids generated from Rett syndrome patients show shorter migration distances and slower migration speeds of mutant radially migrating neurons with more tortuous trajectories.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto, Branka Hrvoj-Mihic ... Fred H Gage
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield, Allison R Najafi ... Kim N Green
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.