7,773 results found
    1. Neuroscience

    Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Sue Ann Koay et al.
    From as early as primary visual cortex and across posterior cortical areas, neural responses to visual pulses during an evidence-accumulation task exhibit a multitude of task-related amplitude modulations/gain changes.
    1. Neuroscience

    Pre-stimulus phase and amplitude regulation of phase-locked responses are maximized in the critical state

    Arthur-Ervin Avramiea et al.
    Critical networks show maximum pre-stimulus phase and amplitude regulation of stimulus-evoked responses.
    1. Neuroscience

    Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively

    Adrian Ponce-Alvarez et al.
    Neurons differ in their impact on collective cortical activity, with sensitive neurons forming a stable topological core, implicated in cortical-state transitions, while peripheral insensitive neurons are more responsive to stimuli.
    1. Neuroscience

    An essential role for MEF2C in the cortical response to loss of sleep in mice

    Theresa E Bjorness et al.
    The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.
    1. Computational and Systems Biology
    2. Neuroscience

    Rate and timing of cortical responses driven by separate sensory channels

    Hannes P Saal et al.
    Signals from different tactile submodalities are integrated optimally to culminate in cortical responses whose rate and timing conveys stimulus information.
    1. Immunology and Inflammation

    Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

    Jialong Yang et al.
    Genetic ablation of Raptor and Rictor in mice revealed critical roles of mTORC1 and mTORC2 in T follicular helper cell differentiation and germinal center responses.
    1. Neuroscience

    Paradoxical response reversal of top-down modulation in cortical circuits with three interneuron types

    Luis Carlos Garcia del Molino et al.
    Computational simulations and mathematical derivations reveal why the response of neural populations to external modulation is sometimes reversed with respect to what intuition would lead to believe in cortical circuits with multiple types of inhibitory neurons.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak et al.
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Neuroscience

    The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

    Olivia K Faull, Kyle TS Pattinson
    Building on previous work (Faull et al, 2016), it shown that the different connectivity profiles of the individual columns of the human periaqueductal gray support their proposed roles in human threat behaviours, such as freezing or fight/flight.
    1. Immunology and Inflammation

    The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

    Heather D Marshall et al.
    Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.

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