3,433 results found
    1. Neuroscience

    Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity

    Amy E Pohodich, Hari Yalamanchili ... Huda Y Zoghbi
    Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.
    1. Medicine
    2. Neuroscience

    Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

    Sophie Leclercq, Hany Ahmed ... Nathalie Delzenne
    Metabolomics analysis identified potential neuroactive metabolites, issued from food and microbial fermentation, that are linked to symptoms of depression, anxiety and alcohol craving.
    1. Neuroscience

    A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

    Ana S Machado, Dana M Darmohray ... Megan R Carey
    Analysis of 3D paw kinematics and whole-body coordination in freely walking mice isolates specific features of gait ataxia and supports the hypothesis that the cerebellum provides an internal forward model for motor control.
    1. Neuroscience

    Increased influence of prior choices on perceptual decisions in autism

    Helen Feigin, Shir Shalom-Sperber ... Adam Zaidel
    Perceptual decisions are influenced by preceding choices to a larger extent in individuals with autism spectrum disorder, such that they demonstrate a greater consistency bias.
    1. Neuroscience

    Increasing adult-born neurons protects mice from epilepsy

    Swati Jain, John J LaFrancois ... Helen E Scharfman
    Increasing adult-born neurons in the dentate gyrus reduces neuronal loss and chronic seizures in female mice using a mouse model of temporal lobe epilepsy.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Neuroscience

    Structural constraints on the emergence of oscillations in multi-population neural networks

    Jie Zang, Shenquan Liu ... Arvind Kumar
    An odd number of inhibitory links in a network are necessary and sufficient to make a network of neuron populations oscillate.
    1. Neuroscience

    Standardized and reproducible measurement of decision-making in mice

    The International Brain Laboratory, Valeria Aguillon-Rodriguez ... Anthony M Zador
    A standard for complex mouse behavior that can be successfully reproduced across laboratories, along with open-access data and tools to implement provide a resource for reproducibility through collaborative open-science approaches.
    1. Cell Biology
    2. Developmental Biology

    Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

    Naonobu Fujita, Wilson Huang ... Amy A Kiger
    Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
    1. Physics of Living Systems

    Hydrodynamics and multiscale order in confluent epithelia

    Josep-Maria Armengol-Collado, Livio Nicola Carenza, Luca Giomi
    Confluent cellular layers display the remarkable ability of supportingmultiscale orientational order, that is the existence of different typeof liquid crystal order at different length scales.

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