512 results found
    1. Cell Biology
    2. Computational and Systems Biology

    A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

    Renat N Khaliullin et al.
    Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.
    1. Computational and Systems Biology
    2. Neuroscience

    Deep Learning: Branching into brains

    Adam Shai, Matthew Evan Larkum
    What can artificial intelligence learn from neuroscience, and vice versa?.
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    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Neuroscience

    A theory of working memory without consciousness or sustained activity

    Darinka Trübutschek et al.
    Visual information can be maintained in non-conscious working memory for several seconds via short-term changes in synaptic weights.
    1. Neuroscience

    The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

    Frans Vinberg et al.
    Molecular, genetic, and functional analysis is used to show that the olfactory Na+/Ca2+, K+ exchanger NCKX4 is expressed in cone photoreceptors and is critical for the wide operating range and high temporal resolution of cone-mediated vision.
    1. Neuroscience

    Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice

    Shu-Hsien Sheu et al.
    A similar pattern of developmental synaptic refinement leads two consecutive synaptic relays to have the same organization suggesting that some general principle of neural organization is at play.
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay et al.
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Neuroscience

    A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

    Yi Bessie Liu et al.
    A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
    1. Cell Biology

    Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

    Anna P Baron et al.
    Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
    1. Developmental Biology
    2. Neuroscience

    Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

    Hao Wu et al.
    The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.

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