Interactions between cortical and subcortical circuits in the mammalian brain flexibly control the flow of information streams that drive decisions by shifting the balance of power both within and between action representations.

Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.

M2 cortex-dorsolateral striatum circuit is functionally altered in Huntington's disease and, by boosting its activity, we reverse symptoms at behavioral, physiological, and morphological level in symptomatic mice.

An odd number of inhibitory links in a network are necessary and sufficient to make a network of neuron populations oscillate.

Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.

The first comprehensive map of all excitatory inputs to the mouse striatum is presented and used to define and demarcate striatal subdivisions, including a previous unappreciated novel subdivision in the posterior striatum.

A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.

The cerebellum sends a functional input to the song-related basal ganglia via the thalamus in songbirds that can modify premotor activity, and it participates to song learning in juvenile birds.

Invasively recorded cortical beta oscillations form whole-brain structural and functional networks that are modulated by dopamine.

Dynamic changes in activity and connectivity of the human subthalamic nucleus reflect whether a decision will be made in haste or with caution.