Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
Cell-type-specific circuit analysis reveals a highly polysynaptic pattern of excitatory feedforward connections along the somatosensory-to-motor loop, from cuneate via VPL thalamus to S1 and M1 cortex and corticospinal neurons.
Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.
Neocortical synapses in layer 4 of the human temporal lobe neocortex were quantitatively characterized, at the subcellular level, using high-end, high-resolution electron microscopy and 3D-volume reconstructions.