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    1. Computational and Systems Biology
    2. Neuroscience

    Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Steven Jack Jerjian, Maneesh Sahani, Alexander Kraskov
    Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.
    1. Neuroscience

    Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

    Anitha Manohar, Guglielmo Foffani ... Karen A Moxon
    After complete spinal transection in adult rats, careful combinations of pharmacological and physical therapies create a novel cortical sensorimotor circuit that may bypass the lesion through biomechanical coupling, allowing animals to recover unassisted hindlimb locomotion.
    1. Neuroscience

    Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury

    Zimei Wang, Adam Romanski ... Murray G Blackmore
    Three-dimensional imaging and automated, brain-wide cell counting yield new insight into the diversity of neurons that connect the brain to the spinal cord and their different sensitivity to spinal cord damage.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling, Somasish Ghosh Dastidar ... Don W Cleveland
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.
    1. Neuroscience

    An afferent white matter pathway from the pulvinar to the amygdala facilitates fear recognition

    Jessica McFadyen, Jason B Mattingley, Marta I Garrido
    A subcortical white matter connection from the pulvinar to the amygdala predicts how well we recognise fearful faces and the strength of feed-forward neural connectivity.
    1. Neuroscience

    Developmental 'awakening' of primary motor cortex to the sensory consequences of movement

    James C Dooley, Mark S Blumberg
    Early in development, before neurons in primary motor cortex are involved in motor control, they undergo a rapid transition in how they process sensory information following sleep and wake movements.
    1. Developmental Biology
    2. Neuroscience

    Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

    Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
    Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
    1. Neuroscience

    Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

    Vanessa M Johnen, Franz-Xaver Neubert ... Matthew F S Rushworth
    Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.
    1. Neuroscience

    Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

    Miki Kaneshige, Kei Obara ... Yukio Nishimura
    Spinal stimulation at balanced currents of excitation and inhibition boosts voluntarily produced torque production.
    1. Neuroscience

    Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

    Kuchuan Chen, Tammy Szu-Yu Ho ... Hugo J Bellen
    The iron/sphingolipid/PDK1/Mef2 pathway is activated in mammals upon loss of Frataxin.