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    1. Developmental Biology
    2. Neuroscience

    Lmx1a is a master regulator of the cortical hem

    Igor Y Iskusnykh, Nikolai Fattakhov ... Victor V Chizhikov
    LIM-homeodomain transcription factor Lmx1a co-regulates multiple developmental processes in the cortical hem, a major signaling center necessary for hippocampus formation in the mammalian brain.
    1. Neuroscience

    Cortico-subcortical β burst dynamics underlying movement cancellation in humans

    Darcy A Diesburg, Jeremy DW Greenlee, Jan R Wessel
    Burst-like neural activity in the β-frequency band conveys inhibitory commands within long-proposed cortico-subcortical networks for motor inhibition, with inhibitory activity in STN preceding thalamic activity, which has strong implications for movement disorders marked by abnormalities in β-bursting.
    1. Neuroscience

    Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

    Ohad Stoler, Alexandra Stavsky ... Ilya Fleidervish
    Optical recordings from L5 cortical pyramidal neurons expressing mitochondria-targeted Ca2+ indicator, mitoGCaMP6m, reveal compartment-specific mitochondrial responses to spike firing and synaptic activity.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger, Wengang Wang ... Bernardo L Sabatini
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
    1. Neuroscience

    All-trans retinoic acid induces synaptic plasticity in human cortical neurons

    Maximilian Lenz, Pia Kruse ... Andreas Vlachos
    The vitamin A derivative, all-trans retinoic acid, induces protein-synthesis-dependent synaptic plasticity in the human brain.
    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia, Christopher Timmermann ... Robin L Carhart-Harris
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Neuroscience

    Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

    Alexa Tompary, Lila Davachi
    Changes in cortical neural ensembles and heightened coupling between the hippocampus and cortex enable the eventual behavioral integration of memories with overlapping sequential information.
    1. Neuroscience

    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

    Achira Roy, Rory M Murphy ... Kathleen J Millen
    Embryonic PI3K-Yap activity regulates apical adhesion and proliferation of neural progenitors lining the lateral ventricular surface, to maintain the smooth, non-folded mouse brain and to prevent developmental hydrocephalus.
    1. Developmental Biology
    2. Evolutionary Biology

    Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

    Cédric Girard-Buttoz, Patrick J Tkaczynski ... Catherine Crockford
    Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
    1. Neuroscience

    Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe

    Nicole Eichert, Emma C Robinson ... Rogier B Mars
    Cross-species alignment based on cortical myelin content can dissociate cortical expansion and relocation from changes in connectivity profiles in the temporal lobe of higher primates.