7,957 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Microbiology and Infectious Disease

    Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

    MengJie Hu et al.
    RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection reveals the RSV-mitochondrial interface as a viable target for therapeutic intervention.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Microbiology and Infectious Disease

    Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

    Ke Peng et al.
    A robust method to quantitatively visualize HIV-1 replication complexes in infected cells shows that these complexes remain associated with the viral capsid beyond nuclear import in primary macrophages.
    1. Neuroscience

    Reconfiguration of functional brain networks and metabolic cost converge during task performance

    Andreas Hahn et al.
    Cognitive performance is supported by symbiotic metabolic and neuro-vascular responses in task-specific brain networks.
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors

    Daniel Blanco-Melo et al.
    The reconstitution of a functional envelope protein from an extinct hominid retrovirus reveals its receptor and an ancient host defense that may have led to the extinction of the virus.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles

    Andrew T Timberlake et al.
    Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann et al.
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.

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