977 results found
    1. Computational and Systems Biology

    Emergence of power law distributions in protein-protein interaction networks through study bias

    David B Blumenthal, Marta Lucchetta ... Martin H Schaefer
    Biased research interest in proteins and aggregation of interactions from multiple studies can explain why node degree distributions in protein-protein interaction networks follow a power law.
    1. Neuroscience

    De novo learning versus adaptation of continuous control in a manual tracking task

    Christopher S Yang, Noah J Cowan, Adrian M Haith
    Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
    1. Cell Biology
    2. Plant Biology

    Photosynthetic sea slugs induce protective changes to the light reactions of the chloroplasts they steal from algae

    Vesa Havurinne, Esa Tyystjärvi
    Slug chloroplasts avoid damage to photosynthesis by maintaining an oxidized electron transfer chain with the help of oxygen-sensitive electron acceptors.
    1. Cell Biology

    Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

    Linda K Krasniewski, Papiya Chakraborty ... Myriam Gorospe
    Single-cell analysis of skeletal mouse reveals highly diverse macrophage subgroups associated with diverse functions and age-related changes.
    1. Evolutionary Biology

    Evolution of diversity in metabolic strategies

    Rodrigo Caetano, Yaroslav Ispolatov, Michael Doebeli
    Analytical and numerical analyses reveal that the number of coexisting species exceeds the number of resource only for the structurally unstable case of linear tradeoff.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

    Kelly A Manthei, Shyh-Ming Yang ... John JG Tesmer
    Structure of lecithin:cholesterol acyltransferase with a covalent acyl-intermediate mimic and a small molecule activator reveals an active conformation and that the enzyme can be activated via its membrane binding domain.
    1. Physics of Living Systems

    Mechanical instability and interfacial energy drive biofilm morphogenesis

    Jing Yan, Chenyi Fei ... Bonnie L Bassler
    Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
    1. Neuroscience

    Adaptation of Drosophila larva foraging in response to changes in food resources

    Marina E Wosniack, Dylan Festa ... Jimena Berni
    Drosophila larvae foraging adapt to different food quality and distributions modulating specific motor programs, as revealed by behavioral and modeling experiments.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

    Stijn van Dorp, Ruoyi Qiu ... Richard S Lewis
    Single-molecule FRET measurements and protein crosslinking reveal the compact structure of quiescent STIM1 and the conformational rearrangements that enable it to activate store-operated calcium entry.
    1. Physics of Living Systems

    Optical mapping of ground reaction force dynamics in freely behaving Drosophila melanogaster larvae

    Jonathan H Booth, Andrew T Meek ... Malte C Gather
    A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.

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