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    1. Evolutionary Biology
    2. Genetics and Genomics

    Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

    José Fabricio López Hernández, Rachel M Helston ... Sarah E Zanders
    Mating phenotypes are diverse in Schizosaccharomyces pombe and the natural variation can impact the spread of wtf meiotic drivers.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst, DH de Vries ... L Franke
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil

    Rachel Lowe, Caio AS Coelho ... Xavier Rodó
    The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics.
    1. Computational and Systems Biology
    2. Neuroscience

    Optimization of energy and time predicts dynamic speeds for human walking

    Rebecca Elizabeth Carlisle, Arthur D Kuo
    Humans often walk in relatively brief bouts whose speed and duration vary dynamically and satisfy an optimal trade-off between effort and time.
    1. Neuroscience

    A causal role for right temporo-parietal junction in signaling moral conflict

    Ignacio Obeso, Marius Moisa ... Jean-Claude Dreher
    Disrupting the right temporo-parietal junction did not change the general motivation to give or adapt behavior to social reputation cues, but specifically reduced the impact of moral-material conflict.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

    James A Watson, Robert J Commons ... Nicholas J White
    The currently recommended adult dose of tafenoquine is insufficient for radical cure in all adults.
    1. Medicine

    Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez, Alyson Haslam ... Vinay Prasad
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.
    1. Genetics and Genomics

    Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

    DeElegant Robinson, Michael Place ... Audrey P Gasch
    The genetic background of Saccharomyces cerevisiae yeast strains influences responses to gene overexpression.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

    Camilo Barbosa, Roderich Römhild ... Hinrich Schulenburg
    Evolutionary trade-offs enhance efficacy of antibiotic therapy by constraining bacterial adaptation in dependence of drug order and trade-off effect size.
    1. Neuroscience

    Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements

    Ali Mashhoori, Saeedeh Hashemnia ... Aaron J Gruber
    The anterior cingulate cortex intermixes a precise spatial map with a cognitive map of the task, and spontaneously recalls multimodal information about unrealized choice outcomes during pauses in behavior after reinforcements.