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  1. Research: Financial costs and personal consequences of research misconduct resulting in retracted publications

    Andrew M Stern, Arturo Casadevall ... Ferric C Fang
    In the first study attempting to formally quantify the deleterious impact of research misconduct on funding sources and publication output, we found that misconduct accounts for a small but substantial portion of American biomedical science funding dollars and damages the productivity and rate of funding acquisition of those who commit misconduct.
    1. Structural Biology and Molecular Biophysics

    Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud

    Michael A Cianfrocco, Andres E Leschziner
    A freely available software environment on Amazon's cloud computing network makes processing of cryo-EM data accessible and affordable.
    1. Epidemiology and Global Health

    Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic

    Pedro Nascimento de Lima, Rosita van den Puttelaar ... Carolyn M Rutter
    Unequal recovery in colorectal cancer screening following the COVID-19 pandemic can widen disparities in colorectal cancer outcomes.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan, Martin Vordermeier ... James LN Wood
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

    Benson Ogunjimi, Lander Willem ... Niel Hens
    An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.
    1. Medicine
    2. Epidemiology and Global Health

    Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households

    Samuel PC Brand, Patrick Munywoki ... David James Nokes
    Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

    Riku Klén, Disha Purohit ... David Gómez-Varela
    The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.
    1. Stem Cells and Regenerative Medicine

    Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

    Mami Matsuo-Takasaki, Sho Kambayashi ... Yohei Hayashi
    Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

    Riham Ayoubi, Joel Ryan ... Carl Laflamme
    Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.
    1. Epidemiology and Global Health

    Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance

    Qixin He, John K Chaillet, Frédéric Labbé
    A novel compartment model identifies the impact of malaria strain diversity on biogeographic drug resistance patterns, supported by empirical evidence.