699 results found
    1. Microbiology and Infectious Disease

    Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

    Shida Shangguan et al.
    Using single-cell CITE-seq to implicate monocytes as the cellular origin of a protective HIV vaccine gene signature.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek et al.
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET

    William N Zagotta et al.
    Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.
    1. Plant Biology

    SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development

    Sonia Accossato et al.
    SUMOylation contributes to the fine-tuning of the proteostatic equilibrium of essential chloroplast protein import receptor TOC159 at early plant development.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural characterization of NrnC identifies unifying features of dinucleotidases

    Justin D Lormand et al.
    Dinucleotidases, specialized enzymes that catalyze the final step in RNA degradation, have evolved independently and repeatedly to fulfill essential roles in cell growth.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

    Jessica P Kuppan et al.
    Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell et al.
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

    Gukui Chen et al.
    The diguanylate cyclase activity of SiaD is activated by its binding partner SiaC thourgh a dynamic mechanism of promoting the formation of active SiaD dimers.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.

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