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    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim et al.
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Physics of Living Systems

    Symmetry breaking meets multisite modification

    Vaidhiswaran Ramesh, J Krishnan
    Network symmetry represents a new vantage point for dissecting complex information processing characteristics in multisite modification, and the breaking of symmetry can confer ordering of modification and absolute concentration robustness.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

    Wan Hua Li et al.
    The first-in-class cell-permeant fluorescent probe provides direct and visual evidence of SARM1 activation in axonal degeneration and identified the first covalent, allosteric inhibitor of SARM1 acting on the NAD-binding pocket in the ARM domain.
    1. Structural Biology and Molecular Biophysics

    Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

    Raji E Joseph et al.
    The first-in-class kinase inhibitor, Ibrutinib, destabilizes its autoinhibited Bruton’s tyrosine kinase (BTK) target, and a remote resistance mutation causes global structural changes that activate BTK catalytic activity.
    1. Neuroscience

    Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

    Javier Díaz-Alonso et al.
    Despite being the key element of the classic model for excitatory synaptic plasticity, the cytoplasmic AMPA receptor C-tail is not required for hippocampal LTP.
    1. Structural Biology and Molecular Biophysics

    Calcium-driven regulation of voltage-sensing domains in BK channels

    Yenisleidy Lorenzo-Ceballos et al.
    Gating currents analysis at different Ca2+ concentrations of BK channels reveals a strong allosteric coupling between Ca2+- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca2+-sites.
    1. Chromosomes and Gene Expression

    Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determination

    Lee F Langer et al.
    The chromatin remodeler and tumor suppressor SMARCB1 acts to restrict superenhancer function to direct neural differentiation of embryonic stem cells while repressing bivalent gene activity in the pluripotent state.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

    Steffen Preissler et al.
    Interdomain linker-mediated oligomerization of the endoplasmic reticulum chaperone protein BiP responds to the unfolded protein burden
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    An internal thioester in a pathogen surface protein mediates covalent host binding

    Miriam Walden et al.
    Bacterial-encoded covalent adhesion is a new molecular principle in host-microbe interactions and may play a key role in host colonization by a wide range of Gram-positive bacteria.
    1. Cell Biology
    2. Genetics and Genomics

    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

    Regina Rillo-Bohn et al.
    Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.