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    1. Neuroscience

    Binary and analog variation of synapses between cortical pyramidal neurons

    Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung
    Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.
    1. Neuroscience

    Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex

    Hao Li, Jingyu Feng ... Jufang He
    CCK released from the neural projections from the rhinal cortex to the motor cortex modulates neural plasticity and facilitates motor skill learning.
    1. Neuroscience

    A theory of working memory without consciousness or sustained activity

    Darinka Trübutschek, Sébastien Marti ... Stanislas Dehaene
    Visual information can be maintained in non-conscious working memory for several seconds via short-term changes in synaptic weights.
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Melody A Cheng ... Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis, Jakob Voigts ... Emery N Brown
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Neuroscience

    Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors

    Michel Fallah, Kenea C Udobi ... Rebekah C Evans
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

    Sobhika Agarwala, Keun-Young Kim ... Owen J Tamplin
    Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.
    1. Neuroscience

    Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

    HiJee Kang, Travis A Babola, Patrick O Kanold
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

    Sweta Parab, Rachael E Quick, Ryota L Matsuoka
    Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.
    1. Medicine

    Extrachromosomal circular DNA: Current status and future prospects

    Yiheng Zhao, Linchan Yu ... Xiang Zhou
    Extrachromosomal circular DNA will hold great promise in future biomedical research and clinical translational application.