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    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood, Qingguang Zhang ... Patrick J Drew
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
    1. Developmental Biology
    2. Neuroscience

    Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification

    Esteban Hoijman, L Fargas ... Berta Alsina
    Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.
    1. Evolutionary Biology

    Spinosaurus is not an aquatic dinosaur

    Paul C Sereno, Nathan Myhrvold ... Lauren L Conroy
    A digital flesh model of the sail-backed dinosaur Spinosaurus was tested and performed very poorly in water, favoring the view of this dinosaur as a two-legged, wading ambush predator of large fish in shallow waterways and not an aquatic dinosaur.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

    Pengfei Xu, Haoze V Yu ... J Gage Crump
    Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.
    1. Developmental Biology

    Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis

    Shannon H Carroll, Sogand Schafer ... Eric C Liao
    During zebrafish embryogenesis, dact1 and dact2 are necessary for axis lengthening and craniofacial morphogenesis, and the protease capn8 is misexpressed in dact1/2 mutants.
    1. Developmental Biology

    scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

    Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit
    Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
    1. Developmental Biology

    Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors

    Colin J Dinsmore, Philippe Soriano
    A novel allele of serum response factor (SRF) reveals distinct co-factor requirements in different developmental contexts, raising issues of redundancy, threshold requirements, or novel co-factor usage.
    1. Developmental Biology

    Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes

    Nick Riddiford, Gerhard Schlosser
    RNA sequencing of the African clawed frog has identified hundreds of putative direct Six1 and Eya1 target genes, including transcriptional regulators of neuronal progenitors and neuronal/sensory differentiation.
    1. Developmental Biology

    Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

    Arun Devotta, Hugo Juraver-Geslin ... Jean-Pierre Saint-Jeannet
    A combination of morpholino-based knockdowns, pharmacological inhibitors, and rescue assays reveal a novel role for natriuretic peptide signaling in the regulation of cell fates in the embryonic ectoderm.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

    Antigoni Gogolou, Celine Souilhol ... Anestis Tsakiridis
    A thorough insight into the previously unrecognised role of a critical developmental regulator known as TBXT in influencing the specification of human trunk neural crest cells, the presumed precursors of the childhood tumour neuroblastoma.