7,635 results found
    1. Plant Biology

    The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant-specific motif

    Upendo Lupanga et al.
    Analysis of the Arabidopsis V-ATPase reveals convergent evolution of differential targeting as well as redundancy of the endosomal and vacuolar isoforms during vegetative development.
    1. Developmental Biology

    Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function

    Matthew J Anderson et al.
    Quantification of fluorescently labeled mRNAs reveals that Fgf4 regulates Notch oscillations in the segmentation clock that controls somitogenesis.
    1. Cell Biology
    2. Developmental Biology

    Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos

    Ashley Rich et al.
    Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Epidemiology and Global Health

    Sense of coherence and risk of breast cancer

    Kejia Hu et al.
    There is little evidence for an association between sense of coherence and risk of breast cancer.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnaporthe oryzae

    Xinyu Liu et al.
    A phosphorylation circuitry balancing among kinase, transcription factor, transcription repressor, and phosphatase in response against host immunity during M. oryzae–rice interaction.
    1. Neuroscience

    Forced choices reveal a trade-off between cognitive effort and physical pain

    Todd A Vogel et al.
    Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

    Khoosheh Khayati et al.
    Autophagy and Lkb1 work synergistically to maintain adult mouse homeostasis and survival.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

    Joseph Shaw et al.
    Exploiting virus-encoded ion channels as drug targets drove a multi-faceted approach to deriving potent small molecules targeting HCV p7, simultaneously providing new insights into its fundamental biology.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Science Forum: A survey of research quality in core facilities

    Isabelle C Kos-Braun et al.
    Responses to a survey reveal how core facilities could improve and encourage good research practices.

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