564 results found
    1. Developmental Biology
    2. Evolutionary Biology

    An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

    Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
    The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

    Vera Vollenweider, Karoline Rehm ... Rolf Kümmerli
    Iron-chelating pyoverdines from environmental Pseudomonas spp. show promising antibacterial activity against key human pathogens through the induction of iron starvation, while associated toxicity for host systems remains low.
    1. Ecology

    Plant-associated CO2 mediates long-distance host location and foraging behaviour of a root herbivore

    Carla CM Arce, Vanitha Theepan ... Ricardo AR Machado
    The larvae of the western corn rootworm use root-emitted CO2 to successfully locate the most suitable host plant.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang, Wenju Sun ... Jian Yan
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Microbiology and Infectious Disease

    A system for functional studies of the major virulence factor of malaria parasites

    Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

    Yingying Wang, Xi Chen ... Kirstin Gutekunst
    Synechocystis switches its redox pools under reducing photomixotrophic conditions from utilizing NAD(H)- to ferredoxin-dependent enzymes and thereby balances its metabolism in a trade-off between energy conservation and chemical driving forces.
    1. Neuroscience

    The modulation of savouring by prediction error and its effects on choice

    Kiyohito Iigaya, Giles W Story ... Peter Dayan
    The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.
    1. Cell Biology
    2. Neuroscience

    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

    Holly H Black, Jessica L Hanson ... Alexandra M Whiteley
    Exploring how UBQLN2 mutations cause ALS leads to the discovery of a pathway by which an ancient retroelement changes gene expression in human cells.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Heterogeneity of the GFP fitness landscape and data-driven protein design

    Louisa Gonzalez Somermeyer, Aubin Fleiss ... Fyodor A Kondrashov
    Orthologous proteins display different mutational robustness that can be leveraged to improve prediction of functional sequences.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle, Maximilian Nguyen, Jeremy Gunawardena
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.

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