5,964 results found
    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii, Margot Wohl ... Kenta Asahina
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett, Sophie Denève, Christian K Machens
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Neuroscience

    Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

    Zoltán Szadai, Hyun-Jae Pi ... Balázs Rózsa
    VIP-expressing cortical interneurons represent organism-level information about reward and punishment for local microcircuits to regulate local processing and plasticity.
    1. Neuroscience

    Analysis of foothold selection during locomotion using terrain reconstruction

    Karl S Muller, Kathryn Bonnen ... Mary M Hayhoe
    The visual information walkers use for path selection during locomotion was revealed by analysis of a three-dimensional numerical representation of the natural terrain.
    1. Computational and Systems Biology
    2. Ecology

    Collaborative hunting in artificial agents with deep reinforcement learning

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
    1. Evolutionary Biology
    2. Plant Biology

    Independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

    Tobias Züst, Susan R Strickler ... Georg Jander
    A gain-of-function in a new chemical defense resulted in no trade-offs and and independent evolution between novel and ancestral defenses, suggesting low redundancy among different defensive chemicals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado, Abhilash Padavannil ... James A Letts
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
    1. Chromosomes and Gene Expression

    RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

    James ZJ Kwan, Thomas F Nguyen ... Sheila S Teves
    TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells.
    1. Cell Biology
    2. Neuroscience

    An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis

    Steven J Del Signore, Charlotte F Kelley ... Avital Adah Rodal
    Autoinhibition allows synaptic endocytic actin regulators to pre-deploy to synaptic membranes at high concentrations and constrains actin assembly to productive events.
    1. Structural Biology and Molecular Biophysics

    Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

    Rizki Tsari Andriani, Yoshihiro Kubo
    A fluorometric analysis under voltage clamp shows the presence of a converged electric field in P2X2 channel with no canonical voltage-sensor and identifies the structural determinants for the voltage-dependent gating.

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