5,964 results found
    1. Immunology and Inflammation

    Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

    Katherine A Deets, Randilea Nichols Doyle ... Russell E Vance
    A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen.
    1. Immunology and Inflammation

    Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

    Ingeborg Streng-Ouwehand, Nataschja I Ho ... Yvette van Kooyk
    Controlled neo-glycosylation of antigens can influence intracellular routing of antigens and the nature and strength of immune response, and should therefore be considered as a major determinant in the design of vaccines against cancer and infectious diseases.
    1. Developmental Biology

    A universal reading network and its modulation by writing system and reading ability in French and Chinese children

    Xiaoxia Feng, Irene Altarelli ... Ghislaine Dehaene-Lambertz
    A cross-cultural study of reading acquisition and reading irmpairment reveals the invariance of the neural correlates of reading across cultures.
    1. Cancer Biology
    2. Immunology and Inflammation

    Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

    Ngoc Lan Tran, Lorena Maria Ferreira ... Giovanni Sitia
    Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.
    1. Evolutionary Biology

    A meta-analysis of the association between male dimorphism and fitness outcomes in humans

    Linda H Lidborg, Catharine Penelope Cross, Lynda G Boothroyd
    While men’s mating success is predicted both by their strength/muscularity, voice pitch, height, and testosterone levels, their reproductive output is only predicted by strength/muscularity.
    1. Stem Cells and Regenerative Medicine

    Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

    Kefei Nina Li, Prachi Jain ... Tudorita Tumbar
    Hair follicle epithelium and skin vasculature remodeling are coordinated during quiescence, and their cross-talking is associated with the timing of stem cell activation.
    1. Immunology and Inflammation

    Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

    Bronwen R Burton, Richard K Tennant ... Harry N White
    Investigation of antibody responses to variant Dengue virus proteins demonstrate new mechanisms that could increase the potential for vaccines to protect against mutable pathogens such as Flu, Dengue and HIV.
    1. Developmental Biology

    Metabolic control of cellular immune-competency by odors in Drosophila

    Sukanya Madhwal, Mingyu Shin ... Tina Mukherjee
    Impact of odor experience on myeloid metabolism and immunity.
    1. Neuroscience

    Corticothalamic phase synchrony and cross-frequency coupling predict human memory formation

    Catherine M Sweeney-Reed, Tino Zaehle ... Alan Richardson-Klavehn
    Direct electrophysiological evidence demonstrates a role for the anterior thalamic nucleus in human memory formation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

    Kim Bich Nguyen, Malte Roerden ... Stefani Spranger
    In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.

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