4,890 results found
    1. Neuroscience

    Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

    Tineke Grent-'t-Jong et al.
    Resting-state MEG-activity and MRS-GABA/Glx measurements reveal that there is a significant shift in excitability during the course of schizophrenia, involving hyperexcitability during the onset and a reduction at chronic stages.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

    Wiebke Nahrendorf et al.
    A novel mouse model of immunization against Plasmodium chabaudi involving infectious mosquito bites and drug-treatment elicits protection against blood-stage malaria parasites, and shows that protection is not necessarily life cycle stage-specific.
    1. Human Biology and Medicine

    Point of View: Strategies from UW-Madison for rescuing biomedical research in the US

    Judith Kimble et al.
    A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
    1. Neuroscience

    Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex

    Jean Laurens et al.
    The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
    1. Cancer Biology

    A generalized theory of age-dependent carcinogenesis

    Andrii Rozhok, James DeGregori
    The multi-stage model of carcinogenesis requires the incorporation of aging-dependent somatic selection and life history-dependent evolution of species-specific tumor suppressor mechanisms in order to generalize carcinogenesis across tissues and species.
    1. Neuroscience

    State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

    Amanda M Willard et al.
    The transition in basal ganglia output from the healthy to the diseased state is biphasic, stereotyped across models, and suggests key time points for delivering therapeutic interventions.
    1. Ecology
    2. Neuroscience

    Patterns of call communication between group-housed zebra finches change during the breeding cycle

    Lisa F Gill et al.
    Call-based vocal communication of individually recorded zebra finches changes in social groups across reproductive stages and is related with successful egg laying.
    1. Neuroscience

    Decoding a neural circuit controlling global animal state in C. elegans

    Patrick Laurent et al.
    Sensory neurons that monitor ambient oxygen control a cascade of responses across multiple layers of interneurons to switch the global state of the nematode C. elegans, reprogramming behavior and gene expression to enable escape from or adaptation to surface exposure.
  1. Early-Career Advisory Group: Championing positive change in academia

    Emmanuelle Vire discusses how eLife’s Early-Career Advisory Group supports early-stage scientists across the world.

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