Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.

Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.

PLK-1/2-mediated SYP-4 phosphorylation is dependent on crossover precursor formation, triggering a switch in the dynamic state of the synaptonemal complex that reduces the formation of further double-strand breaks at late meiotic prophase.

The structure of a multi-protein DNA recombination reaction intermediate reveals how regulation is achieved by protein-mediated DNA wrapping around a core enzyme-substrate complex.

Local infusion of bicarbonate into hepatocellular carcinoma markedly enhances local tumor control by transarterial chemoembolization.

Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.

Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.

A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.

Sleep deprivation enhances energy-dense food choices and encoding of olfactory information in the human brain.

Cellular and genetic approaches reveal that exposure of a normally buried nuclear export signal (NES)-like sequence mediates export of ALS-linked mutant and misfolded wild-type SOD1 to the cytoplasm by CRM1.