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    1. Cell Biology
    2. Chromosomes and Gene Expression

    The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing crossover formation in C. elegans

    Bhumil Patel, Maryke Grobler ... Needhi Bhalla
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

    Regina Rillo-Bohn, Renzo Adilardi ... Abby F Dernburg
    Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.
    1. Neuroscience

    Semantic relatedness retroactively boosts memory and promotes memory interdependence across episodes

    James W Antony, America Romero ... Kelly A Bennion
    The more semantically related a later experience is to an earlier one (along multiple dimensions), the more likely humans are to think back to and strengthen the memory of the earlier experience and mentally link the two experiences.
    1. Neuroscience

    PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron

    Lin Cai, Taiyu Fan ... Shaoqun Zeng
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes

    Daniel B Cortes, Karen L McNally ... Francis J McNally
    Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

    Erik Toraason, Alina Salagean ... Diana E Libuda
    To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also specifically inhibits error prone repair of DNA breaks during meiotic prophase I.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex

    Andrew Ryan Passer, Shelly Applen Clancey ... Marco A Coelho
    A novel form of self-fertility evolved in Cryptococcus depauperatus, a close relative to the human pathogenic Cryptococcus species, in which sexual development is attained by self-signaling of a cognate pheromone and pheromone-receptor pair.
    1. Cell Biology
    2. Genetics and Genomics

    Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

    Heyun Guo, Ericca L Stamper ... Peter M Carlton
    Opposing activities of ATR kinase and PP4 phosphatase balance phosphorylation of the protein DSB-1 to produce sufficient but not excessive amount of DNA double-strand breaks during meiotic prophase in Caenorhabditis elegans.
    1. Biochemistry and Chemical Biology

    Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

    Matthew A Mitsche, Jeffrey G McDonald ... Jonathan C Cohen
    Cells use two interdigitated biosynthetic pathways that can be regulated independently to produce diverse bioactive sterols.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion

    Yann Duroc, Rajeev Kumar ... Valérie Borde
    Meiotic cells employ a specific pathway to limit the amount of gene conversion occuring at recombination sites.