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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

    Nandish Khanra et al.
    Structures of the GluK2/K5 kainate receptor reveal the heteromer architecture and how the receptor organizes in apo, antagonist-bound, and desensitized states.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

    Jing Xue et al.
    Cryo-EM analysis of human ZnT8 reveals a large conformational change of TMD during the transport cycle.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of VASH1-SVBP bound to microtubules

    Faxiang Li et al.
    Cryo-electron microscopy structure of vasohibin 1 bound to microtubules reveals how this enzyme prefers to remove the C-terminal tyrosine of α-tubulin in the microtubule lattice.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

    Marcello Clerici et al.
    Structural, biochemical, and proteomic analyses of a four-subunit core module of the cleavage and polyadenylation specificity factor complex reveal its molecular architecture and specific determinants of polyadenylation signal recognition in human mRNAs.
    1. Structural Biology and Molecular Biophysics

    Architecture of the human mTORC2 core complex

    Edward Stuttfeld et al.
    The structure of the mammalian target of rapamycin complex 2 (mTORC2) reveals the architecture of the complex and explains the structural basis of rapamycin insensitivity.
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin et al.
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

    Nicholas R Ader et al.
    Correlative microscopy and electron cryo-tomography on apoptotic HeLa cells reveal remodeling of outer and inner mitochondrial membranes, Bax cluster ultrastructure and ATP synthase reorganization in ruptured mitochondria.
    1. Biochemistry and Chemical Biology

    Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

    Eva Plesch et al.
    Direct and selective activation of TRPML2 promotes macrophage migration through release of CCL2.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the disaggregase activity and regulation of Hsp104

    Alexander Heuck et al.
    Protein disaggregases employ two mechanically-linked ATPase rings that are under steric control by a wrapped-around coiled-coil belt.
    1. Cell Biology

    Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae

    Galina V Beznoussenko et al.
    The soluble cargo protein albumin traverses the Golgi stack at much faster rates than procollagen aggregates, by diffusion via intercisternal continuities.