Karin Schrieber, Sarah Catherine Paul ... Elisabeth Johanna Eilers
Inbreeding compromises floral traits and reduces pollinator visitation rates disproportionally in female relative to male individuals in a dioecious plant and may thus interfere with the equilibrium of a complex co-evolutionary plant-insect relationship.
Floral scent and nectar are highly variable in natural populations and both traits can influence outcrossing rates differently for different pollinators and increase future herbivory.
Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
Pradeep Bhandari, David Vandael ... Peter Koppensteiner
The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
Aviv Regev, Sarah A Teichmann ... Human Cell Atlas Meeting Participants
Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
Jenny I Aguilar, Mary Hongying Cheng ... Aurelio Galli
A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
Katharina van Pee, Alexander Neuhaus ... Özkan Yildiz
The near-atomic cryoEM pore complex structure of pneumolysin, the main virulence factor of Streptococcus pneumoniae, shows how the individual domains rearrange during the pore formation.
Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.