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    1. Ecology
    2. Evolutionary Biology

    Inbreeding in a dioecious plant has sex- and population origin-specific effects on its interactions with pollinators

    Karin Schrieber, Sarah Catherine Paul ... Elisabeth Johanna Eilers
    Inbreeding compromises floral traits and reduces pollinator visitation rates disproportionally in female relative to male individuals in a dioecious plant and may thus interfere with the equilibrium of a complex co-evolutionary plant-insect relationship.
    1. Ecology
    2. Plant Biology

    How scent and nectar influence floral antagonists and mutualists

    Danny Kessler, Mario Kallenbach ... Ian T Baldwin
    Floral scent and nectar are highly variable in natural populations and both traits can influence outcrossing rates differently for different pollinators and increase future herbivory.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

    Pradeep Bhandari, David Vandael ... Peter Koppensteiner
    The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev, Sarah A Teichmann ... Human Cell Atlas Meeting Participants
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar, Mary Hongying Cheng ... Aurelio Galli
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

    Katharina van Pee, Alexander Neuhaus ... Özkan Yildiz
    The near-atomic cryoEM pore complex structure of pneumolysin, the main virulence factor of Streptococcus pneumoniae, shows how the individual domains rearrange during the pore formation.
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Membrane binding controls ordered self-assembly of animal septins

    Agata Szuba, Fouzia Bano ... Gijsje H Koenderink
    Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.