134 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of opening and closing of the bacterial replicative helicase

    Jillian Chase et al.
    Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
    1. Structural Biology and Molecular Biophysics

    PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

    Sergey Gorelick et al.
    The PIE-scope resolves the limitations in correlative cryo-focused ion beam milling by adding robustness and ease of use to the workflow.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

    Jiajie Diao et al.
    A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
    1. Structural Biology and Molecular Biophysics

    TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

    Jing Xue et al.
    Cryo-EM structure of human TMEM120A reveals that it is a coenzyme A-binding protein and is unlikely to function as a mechanosensitive channel as was recently proposed.
    1. Neuroscience

    Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

    Hiromi Tamada et al.
    Cryo preservation of brain tissue reveals dendritic spines with thinner necks compared to those prepared with chemical fixation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj et al.
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Developmental Biology

    Identification and functional characterization of muscle satellite cells in Drosophila

    Dhananjay Chaturvedi et al.
    Modeling adult muscle homeostasis, maintenance and repair will now be possible in Drosophila with the discovery of satellite cells equivalents in flight muscles.
    1. Structural Biology and Molecular Biophysics

    Structure of the bacterial ribosome at 2 Å resolution

    Zoe L Watson et al.
    High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott et al.
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.

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