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Mitochondrial quality control in the germline is mediated by regulators of both programmed cell death and the aging program.

Characterization of an extra-membrane site in I_Ks formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

Using advanced volume electron microscopy, the ultrastructural and spatial organisation of Leishmania parasites strongly adhered to the gut of its sand fly vector was defined.

Benzene mapping simulations of envelope protein rafts from six different flaviviruses reveal a conserved cryptic site whose cluster of ionisable residues is likely responsible for orchestrating pH-dependent conformational changes during fusion, thereby representing an attractive target for antiviral development.

Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.

A cryptic pocket in the myosin motor domain selectively opens in molecular dynamics simulations, and the probability of pocket opening is predictive of how potently a compound will inhibit a particular myosin motor.

The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.

Diffusion of differently sized proteins in bacterial cytoplasm is nearly Brownian and consistent with the Stokes-Einstein relation, once protein shape and cell geometry are taken into account, and effects of various perturbation can be described as changes in cytoplasmic viscosity.

The calibration of decision thresholds will provide evidence for the optimal use of in silico predictors for the standardised classification of globin gene variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology framework.