58 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Template switching during DNA replication is a frequent source of adaptive gene amplification.
    1. Cell Biology

    Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

    Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
    β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

    Maruti Nandan Rai, Qing Lan ... Koon Ho Wong
    The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
    1. Microbiology and Infectious Disease

    The target of rapamycin signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

    Guoqi Li, Xiaohong Cao ... Shihua Wang
    Exploration of the target of rapamycin pathway in Aspergillus flavus reveals critical regulatory elements influencing aflatoxin synthesis and stress tolerance, offering potential targets for antifungal strategies.
    1. Plant Biology

    Distinct effects of phyllosphere and rhizosphere microbes on invader Ageratina adenophora during its early life stages

    Zhao-Ying Zeng, Jun-Rong Huang ... Han-Bo Zhang
    An inoculation experiment shows phyllosphere microbiome plays an important role in invader Ageratina adenophora population establishment by killing seedlings at very early growth stage.
    1. Biochemistry and Chemical Biology

    Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs

    Chi-Ning Chuang, Hou-Cheng Liu ... Ting-Fang Wang
    Noncanonical usage of stop codons in ciliates expands structurally flexible Q-rich domains and coevolves with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.
    1. Microbiology and Infectious Disease

    Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

    Yang Meng, Yue Ni ... Chen Ding
    Isw1 acts as a master regulator in modulating the expression of drug-resistance genes, and this regulatory mechanism is dependent on the interaction of Isw1 acetylation and ubiquitination.

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