58 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini, Lauren J McIver ... Nicola Segata
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

    Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
    β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Template switching during DNA replication is a frequent source of adaptive gene amplification.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen

    David E Cook, H Martin Kramer ... Bart P H J Thomma
    Assessment of DNA methylation, histone modifications, and DNA accessibility revealed that physical DNA characteristics are associated with adaptive genome evolution in the broad host range plant pathogenic fungus Verticillium dahliae.
    1. Cell Biology

    Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

    Krishnendu Guin, Yao Chen ... Kaustuv Sanyal
    Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

    Courtney R Johnson, Marc G Steingesser ... Michael A McMurray
    A naturally-occurring small molecule acts as a chemical chaperone in vivo to alter the folding of a budding yeast septin and promote an oligomerization pathway that was lost during evolution.
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology

    ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion

    Amy J Curwin, Nathalie Brouwers ... Vivek Malhotra
    The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).
    1. Evolutionary Biology

    Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

    Hironori Funabiki, Isabel E Wassing ... Thomas Carroll
    Coevolution analysis suggests that a DNA methylation-related role for the nucleosome remodeling ATPase HELLS and its activator CDCA7 was broadly inherited from the last eukaryotic common ancestor.

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