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    1. Developmental Biology
    2. Evolutionary Biology

    Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

    Zsolt Merényi, Máté Virágh ... László G Nagy
    Allele-specific expression, natural antisense transcripts, and developmental gene expression, but not RNA editing or developmental hourglass, act in concert to shape the transcriptome during the fruiting body formation of complex multicellular fungi.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet, Remi Peyraud ... Sylvain Raffaele
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
    1. Immunology and Inflammation

    Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

    Edwin Ardiansyah, Julian Avila-Pacheco ... Nguyen Thuy Thuong Thuong
    High cerebrospinal fluid tryptophan levels consistently predict increased mortality in HIV-infected and -uninfected patients in Vietnam and Indonesia.
    1. Genetics and Genomics

    Comprehensive re-analysis of hairpin small RNAs in fungi reveals loci with conserved links

    Nathan R Johnson, Luis F Larrondo ... Elena A Vidal
    A critical assessment of published microRNA/microRNA-like provides clues on features and conservation of these hairpin RNAs in fungi in addition to a centralized loci annotation resource for the community.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

    Maruti Nandan Rai, Qing Lan ... Koon Ho Wong
    The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
    1. Microbiology and Infectious Disease

    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

    Nicholas Rinkenberger, Michael E Abrams ... L David Sibley
    Overexpression of interferon-stimulated genes revealed a role for RARRES3 in restricting growth of Toxoplasma gondii by inducing early egress from human cells.
    1. Genetics and Genomics

    A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition

    Tyler C Detomasi, Adriana M Rico-Ramírez ... N Louise Glass
    Allorecognition in Neurospora crassa requires CWR-1 (cell wall remodeling protein), an essential process that ensures identity of an interconnected fungal syncytial colony and requires the CWR-1 polysaccharide monooxygenase domain, but not its catalytic activity.
    1. Genetics and Genomics

    Allorecognition: Knowing friend from foe

    Magnus Hallas-Møller, Katja S Johansen
    How does a protein at the cell wall determine if a newly encountered fungus is safe to fuse with?
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

    Danish Khan, Dongju Lee ... Vytas A Bankaitis
    A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.