464 results found
    1. Structural Biology and Molecular Biophysics
    2. Stem Cells and Regenerative Medicine

    ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

    Nataliya Nady et al.
    The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.
    1. Structural Biology and Molecular Biophysics

    Revealing an outward-facing open conformational state in a CLC Cl/H+ exchange transporter

    Chandra M Khantwal et al.
    The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.
    1. Structural Biology and Molecular Biophysics

    Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

    Jonathan M Philpott et al.
    A conformational switch in the Casein Kinase 1 activation loop controls substrate preference to regulate the abundance of the clock protein PERIOD2 and circadian timekeeping.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou et al.
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou et al.
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis

    Ashutosh Pudasaini et al.
    In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.
    1. Structural Biology and Molecular Biophysics

    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

    Stefano Pernigo et al.
    X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu et al.
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Crystal structure of an HIV assembly and maturation switch

    Jonathan M Wagner et al.
    Folding and unfolding of a 6-helix bundle controls HIV assembly and maturation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen et al.
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.

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