Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.

A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.

The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.

Novel imaging experiments suggest that fruit flies modify their neural circuitry for walking at slow, medium and fast speeds, and that proprioception is not essential for coordinated walking.

A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.

Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.

A combination of direct-electron detectors and statistical movie processing allows ribosome cryo-EM structures to be determined to resolutions that were previously only attainable by X-ray crystallography.

Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.

Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.

The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.