Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
P Christiaan Klink, Xing Chen ... Pieter R Roelfsema
Within-species comparison of population receptive fields determined with fMRI and electrophysiology in nonhuman primates reveals the neuronal basis of blood-oxygen-level-dependent-based retinotopy.
Radhika A Varier, Theodora Sideri ... Folkert J van Werven
N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
Ricardo A Cordova, Jagannath Misra ... Kirk A Staschke
The ISR kinase GCN2 is critical for maintaining tumor amino acid levels to facilitate growth, suggesting a novel therapeutic strategy for the treatment of prostate cancer by inducing starvation for essential amino acids.
Chang Hoon Lee, Hongwei H Zhang ... Joshua M Farber
The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.
Christopher T Boughter, Martin Meier-Schellersheim
A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
Amicia D Elliott, Adama Berndt ... Benjamin H White
The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.
Th2 cell heterogeneity was revealed by combined transcriptome and T-cell receptor sequencing of single Th2 cells from lung and lymph node of helminth-infected mice and led to identification of a helminth-specific T-cell receptor.
F Emil Thomasen, Matthew J Cuneo ... Kresten Lindorff-Larsen
Self-association of speckle-type POZ protein (SPOP), a substrate adaptor in the ubiquitin proteasome system, is studied by combining small-angle X-ray scattering and molecular dynamics simulations to reveal the structure of the protein assemblies in solution.
