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    1. Neuroscience

    Neuroelectrophysiology-compatible electrolytic lesioning

    Iliana E Bray, Stephen E Clarke ... Paul Nuyujukian
    Neuronal loss can be studied by passing electrical current through the same electrodes used for neuron measurement without disrupting recording ability.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet, Mark J Roberts ... Peter De Weerd
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction

    Sven Schenk, Christian Krauditsch ... Florian Raible
    A small brain-derived lipid prevents bristle worms from entering maturation and death, challenging current views of hormone evolution and pesticide specificity.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué, Vera van Hoeven ... Kiki Tesselaar
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Structural Biology and Molecular Biophysics

    Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex

    Artem Y Lyubimov, Monarin Uervirojnangkoorn ... Axel T Brunger
    Building on previous work (Uervirojnangkoorn et al., 2015), we demonstrate how improved methods for processing XFEL diffraction data enable the determination of structures from poorly diffracting crystals.
    1. Developmental Biology

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström, Melanie L Lawrence ... Peter Hohenstein
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Neuroscience

    MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

    Thomas Templier
    The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and electron microscopy.
    1. Cell Biology
    2. Physics of Living Systems

    Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity

    Raimund Schlüßler, Kyoohyun Kim ... Jochen Guck
    The combination of optical diffraction tomography and Brillouin microscopy in a single setup enables to quantitatively map the viscoelastic properties of cellular compartments such as aggregates and stress granules in vivo.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay, Emre Kiciman ... Andrey Rzhetsky
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Structural Biology and Molecular Biophysics

    Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Abhilash Padavannil, Prithwijit Sarkar ... Yuh Min Chook
    In an unusual complex that is not dissociated by RanGTP alone, Importin-9 sequesters the H2A-H2B core from promiscuous interactions.