This four-DNA methylation signature demonstrates potential as a novel independent prognostic indicator for risk-stratifying patients with CM.

The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.

Mice get melanoma faster when they have common, inherited variants in a few genes that control cell-wide changes but also respond to the environment.

Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.

The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.

The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.

TP63 regulates NRG1 in squamous cell cancers, and targeting of NRG1 induces cancer cell differentiation thereby NRG1 is a potential therapeutic target in squamous cell cancers.

The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.

Mutations in the DNA of ovarian cyst fluid can inform the need for surgery and indicate the type of neoplastic lesion present.

Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.