1,293 results found
    1. Neuroscience

    Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

    Ashley L Juavinett et al.
    A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
    1. Neuroscience

    Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T

    Kevin R Sitek et al.
    MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

    Zhicheng Zuo et al.
    The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
    1. Neuroscience

    Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control

    Rebecca A Callahan et al.
    Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

    Lu Yu et al.
    Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
    1. Neuroscience

    MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

    Thomas Templier
    The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and electron microscopy.
    1. Neuroscience

    Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1

    Amy M LeMessurier et al.
    Sensory enrichment creates a more columnar, less salt-and-pepper whisker map in somatosensory cortex, showing that impoverished experience contributes to intermixed tuning in rodent sensory maps.
  1. Open book

    Innovator Story: Unlocking knowledge from PDFs

    Patrice Lopez’s commitment to learning and contributing open-source led to the creation of a powerful, versatile tool for knowledge extraction and annotation.
    1. Cell Biology
    2. Neuroscience

    Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

    Veronica Cloud et al.
    An unbiased biochemical screen reveals a direct link between gene regulation and actin cytoskeleton remodeling.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

    Dajun Sang et al.
    Tight regulation of a central developmental kinase cascade evolved through two key mutations.

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