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    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

    Fang Huang, Trang TT Nguyen ... Koh Fujinaga
    Cyclin T1 phosphorylation determines levels of P-TEFb via stabilizing interactions between cyclin T1 and CDK9.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis

    Enjie Li, Mingyue Xia ... Zhigang Guo
    Biochemical approaches and cellular experiments show a novel effect of METTL3 on homologous recombination repair and chemotherapeutic response via the m6A-YTHDC1-dependent regulation of the EGF/RAD51 axis.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg, Nancy Chang ... Marc W Kirschner
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra, Mohammad Zeeshan ... Mathieu Brochet
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Cell Biology

    Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

    Olga Afonso, Colleen M Castellani ... Helder Maiato
    Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

    Edgar M Medina, Jonathan J Turner ... Nicolas E Buchler
    Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
    1. Cell Biology

    Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

    S Zachary Swartz, Hieu T Nguyen ... Arminja N Kettenbach
    Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.
    1. Cell Biology

    Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

    Ana Maria G Dumitru, Scott F Rusin ... Duane A Compton
    Quantitative phosphoproteomics defines the substrates for Cyclin A/Cdk1 kinase during early mitosis and follow up studies validate that one identified substrate, MYPT1, influences the stability of k-MT attachments by regulating Plk1.