A long non-coding RNA removes the transcriptional repressor p50 to regulate recruitment of co-activator p300 and RNA Polymerase II complexes to activate the COX-2 gene in human mammary epithelial cells and macrophages.

Cell-specific pathways regulate lipid transmitters and neuroinflammation in the brain.

Indomethacin, a nonsteroidal anti-inflammatory drug, alters the composition of the intestinal microbiota, and the intestinal microbiota affect the pharmacokinetics of indomethacin.

Mechanistically distinct COX-2 inhibitors reduce stress-induced behavioral pathology via unique multimodal molecular mechanisms, and could be used to treat mood disorders.

PAK1 regulates inhibitory synaptic transmission in mice through a cyclooxygenase-2 dependent restriction in tonic, but not phasic, secretion of endocannabinoids.

Salicylic acid, the precursor to aspirin, is an anti-tumor agent that blocks protein acetylation.

Excitatory and inhibitory cortical neurons drive parallel vasodilatory pathways, while vasoconstriction is mediated exclusively by inhibition acting via Neuropeptide Y binding to Y1 receptors.

Local tissue hypoxia follows seizures, is responsible for postictal behavioural dysfunction rather than the seizures per se and can be treated.

The bridging of bioengineering and cell culture techniques provides a transformative platform to investigate human biology within a 3-dimensional extracellular matrix over prolonged periods with multiplex readouts.

CO₂/H⁺-dependent purinergic signaling by astrocytes provides specialized control of vascular tone in a brainstem respiratory center in a manner that contributes to respiratory behavior.