Browse the search results

Astrocyte signaling can activate the firing of gonadotropin-releasing hormone neurons and stimulate hormone release.

Progesterone mediates nongenomic signaling in Xenopus oocyte meiosis by activating a PLA2 activity that requires two membrane receptors ABDH2 and mPRß.

Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.

Gut microbiota-derived gamma-aminobutyric acid is identified as a key metabolite that metformin protect from hepatic ischemia/reperfusion injury.

The new drug 3,6’-dithiopomalidomide mitigates key markers of neuronal death and neuroinflammation and improves acute behavioral outcome measures in traumatic brain injury, a common, debilitating disorder that lacks effective treatment.

Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.

The metabolic readout of endothelial function in the microvessels-on-a-chip facilitates mechanistic studies and detection of biomarkers for microvascular diseases in a physiological relevant environment.

Increasing adult-born neurons in the dentate gyrus reduces neuronal loss and chronic seizures in female mice using a mouse model of temporal lobe epilepsy.

Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.

The role of placental aging and metabolic stress in driving labor onset is demonstrated, with a novel mouse model of preterm labor in which injection of a prolyl hydroxylase inhibitor stabilizes placental hypoxia-inducible factor 1 and significantly shortens gestational length.