Connexin 43 hemichannel activation associated with prostaglandin release in osteocytes plays an important role in anabolic function of mechanical loading on bone tissue and hemichannels could be a potential new therapeutic target for treating bone loss and osteoporosis.
Embryo-derived TNF promotes CPLA2α phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.
The novel action of RGS10 in epithelial–mesenchymal transition in breast cancer is dependent on LNC2 and miR-539-5p, which is identified as a prognostic biomarker for early distant metastasis in breast cancer.
UV irradiation, a major cause of skin damage, leads to selective loss of fibroblasts from the upper dermis via a deregulated inflammatory response, and infiltrating T cells can promote fibroblast survival in UV irradiated skin.
Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
Liku B Tezera, Magdalena K Bielecka ... Paul T Elkington
The bridging of bioengineering and cell culture techniques provides a transformative platform to investigate human biology within a 3-dimensional extracellular matrix over prolonged periods with multiplex readouts.
