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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

    Kanchan Gupta et al.
    A facile method is implemented to modify membrane proteins with biophysical reporters using cysteine-independent approaches in live cells.
    1. Plant Biology

    The chloroplast 2-cysteine peroxiredoxin functions as thioredoxin oxidase in redox regulation of chloroplast metabolism

    Mohamad-Javad Vaseghi et al.
    The chloroplast 2-cysteine peroxiredoxin is central player and missing link in the chloroplast thiol-disulfide redox regulatory network, and participates in oxidative inactivation of reductively activated enzymes in photosynthesis.
    1. Biochemistry and Chemical Biology

    Comment on ‘YcgC represents a new protein deacetylase family in prokaryotes’

    Magdalena Kremer et al.
    We applied a combined synthetic biological, biochemical and mass-spectrometric approach to show that YcgC is not a member of a novel lysine deacetylase class in prokaryotes.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

    Tao-Hsin Chang et al.
    The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    Unravelling druggable signalling networks that control F508del-CFTR proteostasis

    Ramanath Narayana Hegde et al.
    Analysis of the mechanism of action of cystic fibrosis corrector drugs reveals signalling pathways potently controlling the proteostasis of the main disease-relevant CFTR mutant.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele et al.
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

    Xiaoyu Zhang et al.
    A posttranslational regulatory mechanism for a Ras family small GTPase could open up new directions to understand and control the Ras family of proteins that are important for physiology and diseases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

    Hari B Kamadurai et al.
    Structural studies reveal the mechanism by which a HECT E3 ubiquitin ligase carries out E2-to-E3-to-substrate ubiquitin transfer and prioritizes target lysines for ubiquitination.
    1. Biochemistry and Chemical Biology

    Ribosomes slide on lysine-encoding homopolymeric A stretches

    Kristin S Koutmou et al.
    Ribosomes undergo an unanticipated movement (‘sliding’) while translating homopolymeric A sequences, which provides a biochemical rationale for the observation that iterated AAA codons are under-represented in gene-coding sequences.