114 results found
    1. Biochemistry and Chemical Biology

    A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene

    Xinlu Chen et al.
    The social amoeba Dictyostelium discoideum employs a terpene synthase-cytochrome P450 metabolic gene cluster to produce a novel trisnorsesquiterpene discodiene.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor

    Corinne L Pender, H Robert Horvitz
    The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.
    1. Genetics and Genomics
    2. Neuroscience

    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

    Renske Erion et al.
    Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda et al.
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Biochemistry and Chemical Biology

    Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

    Ryan Paxman et al.
    The small molecule, 147, is a pro-drug that preferentially activates ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins involved in regulating ATF6 activity.
    1. Ecology
    Drosophila illustration

    The Natural History of Model Organisms: The secret lives of Drosophila flies

    Therese Ann Markow
    After decades of intensive research, D. melanogaster and its relatives could provide important tools for investigating future biological questions about human health and environmental change, but only if we better understand their natural history.
    1. Cell Biology

    Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7

    Patricia Marmol et al.
    The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

    Ruihua Ma et al.
    Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

    Corinne von Känel et al.
    Mitochondrial inner membrane translocation of presequence-containing proteins by the single bifunctional TIM complex of T. brucei requires an non-canonical J domain-containing protein.
    1. Biochemistry and Chemical Biology

    Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

    Masatoshi Miyamoto et al.
    (O-Acyl)-ω-hydroxy fatty acids and their derivatives, produced by the fatty acid ω-hydroxylase Cyp4f39, form a lipid polarity gradient in the lipid layer of the tear film and prevent dry eye.

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