82 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Ignacio Moraga et al.
    Synthetic cytokines engage new signaling programs with therapeutic potential.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Cell Signaling: Extraordinary effects of unnatural pairings

    Alejandro Villarino, John J O'Shea
    Engineered molecules based on human cytokines have potential uses in research and medicine.
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IRF4 haploinsufficiency in a family with Whipple’s disease

    Antoine Guérin et al.
    Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.
    1. Developmental Biology and Stem Cells
    2. Chromosomes and Gene Expression

    Cancer-associated TERT promoter mutations abrogate telomerase silencing

    Kunitoshi Chiba et al.
    TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

    Alexander J Martinko et al.
    Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

    Tiemo J Klisch et al.
    Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan et al.
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Domain-swapped T cell receptors improve the safety of TCR gene therapy

    Michael T Bethune et al.
    Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology and Stem Cells

    ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

    Nataliya Nady et al.
    The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon et al.
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.

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