109 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Curated by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais et al.
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.
    1. Cell Biology
    2. Immunology and Inflammation

    Diverse stimuli engage different neutrophil extracellular trap pathways

    Elaine F Kenny et al.
    NETs induction, a central component of the innate immune response, utilises assorted signalling pathways as demonstrated through the analysis of healthy and patient neutrophils treated with five distinct stimuli.
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Cell Biology
    2. Immunology and Inflammation

    Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

    Alejandro Villarino et al.
    Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.
    1. Immunology and Inflammation
    2. Neuroscience

    Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

    Melissa A Lopes Pinheiro et al.
    Antigen-specific control of CD4+ T cell trans-migration by brain endothelial cells via presentation of CNS-derived antigens in MHC-II molecules.
    1. Immunology and Inflammation

    Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

    Rhoanne C McPherson et al.
    Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

    Stefan Heinrichs et al.
    Reduced expression of MYBL2 contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

    Alexander J Martinko et al.
    Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.

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