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    1. Genetics and Genomics

    Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross

    Kaushik Renganaath et al.
    Yeast promoters can harbor multiple natural DNA variants that influence gene expression, interact genetically, evolve under negative selection, alter transcription factor motifs, and remain challenging to predict.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Cell Biology

    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation

    Maria Fomicheva, Ian G Macara
    TRAF3, a negative regulator of noncanonical NF-κB signaling, maintains epithelial cell quiescence at confluence, and its loss triggers upregulation of immunity genes and prevents entry into G0 at high cell density.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

    Rozenn Riou et al.
    A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.
    1. Neuroscience

    Small molecule cognitive enhancer reverses age-related memory decline in mice

    Karen Krukowski et al.
    Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott et al.
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Cell Biology
    2. Computational and Systems Biology

    The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

    Jennifer EL Diaz et al.
    The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha et al.
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The effect of hybridization on transposable element accumulation in an undomesticated fungal species

    Mathieu Hénault et al.
    Transposable elements are not reactivated in natural hybrids of the yeast Saccharomyces paradoxus, but their accumulation is genotype-specific and is not predicted by the evolutionary divergence between a hybrid's parents.